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Abstract #3838

Intraprostatic Lipid Spectroscopic Imaging of the Prostate Cancer

Xin Li 1 , Jackilen Shannon 1 , Mark G Garzotto 1,2 , Chris Amling 1 , William J Woodward 1 , George Thomas 1 , Elizabeth Dacey 1,2 , Xiaohua Wang 1,2 , Paige Farris 1 , Wesley Stoller 2 , Ann Martinez Acevedo 1 , Amy Palma 1 , Manoj K Sammi 1 , William D Rooney 1 , Fergus V Coakley 1 , and Jonathan Q Purnell 1

1 Oregon Health & Science University, Portland, Oregon, United States, 2 Portland VA Medical Center, Portland, Oregon, United States

The lipogenic fatty acid synthase (FAS) is responsible for de novo fatty acid and triglyceride synthesis in tissue. Recently, FAS has been characterized as an oncogene and its overexpression is reported in several cancers which include that of the prostate. The altered lipid deposition of cancerous tissue thus can potentially be an independent biomarker for cancer aggressiveness monitoring. In this work, MR spectroscopic imaging (MRSI) is used to quantify prostatic lipid concentration for prostate cancer.

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