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Abstract #3839

Zone Specific ADC + DCE-MRI Composite Maps to Aid in the Detection and Evaluation of Prostate Cancer

Naira Muradyan 1 , Osama Elbuluk 2 , Baris Turkbey 2 , Sandeep Sankineni 2 , Maria J Merino 3 , Senthil Periaswamy 1 , Marcelino Bernardo 2 , Francois Cornud 4 , and Peter L Choyke 2

1 iCAD, Inc., Nashua, NH, United States, 2 Molecular Imaging Program, NCI, NIH, Bethesda, MD, United States, 3 Laboratory of Pathology, NCI, NIH, Bethesda, MD, United States, 4 Tourville Imaging Centre, Paris, France

This study describes a combined analysis method of Diffusion Weighted and Dynamic Contrast Enhanced MRI for prostate imaging, which minimizes the need for separate evaluation of these sequences. Images of 105 patients from two sites were used retrospectively to develop and test the prostate zone-specific composite colormaps, showing better accuracy than standalone Apparent Diffusion Coefficient outcome. Such objective display of combined information, which could be easily added to routine imaging, may be useful for lesion visualization, evaluation and minimizing reader variability during multiparametric prostate imaging.

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