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Abstract #3840

Performance of High b-Value DWI in identifying high risk prostate cancer patients

Francesca Mertan 1,2 , Harsh K Agarwal 2,3 , Sandeep Sankineni 2 , Marcelino Bernardo 2,4 , Dagane Daar 2,4 , Maria Merino 2 , Bradford Wood 2 , Peter Pinto 2 , Peter L Choyke 2 , and Baris Turkbey 2

1 Grove City College, Grove City, PA, United States, 2 National Institutes of Health, Bethesda, MD, United States, 3 Philips Research NA, Briarcliff Manor, New York, United States, 4 Leidos Biomedical Research Inc., Frederic National Laboratory for Cancer Research, Frederick, MD, United States

ADC maps have been shown to detect and stage prostate cancer. However, at high b-value (b>800mm/s2) DWI signal from tumor tissue does not follow the mono-exponential diffusion decay. Therefore high b-value DWI is typically accessed as part of prostate MRI reading. In this abstract we have shown that the performance of high b-value DWI to detect high risk prostate cancer patients improves with the increase in b-value and its performance did not change significantly with the increase in data acquisition time from 23msec to 102msec for b≥0s/mm2 DWI. High b-value DWI also performed better than ADC from b≤750s/mm2.

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