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Abstract #3841

Hyperpolarized Lactate Production Correlates with Gleason Grade in Patient-Derived Tissues of Prostate Cancer

Renuka Sriram 1 , Mark Van Criekinge 1 , Justin DeLos Santos 1 , Daniel B Vigneron 1 , Robert Bok 1 , Donna Peehl 2 , Kayvan Rahimi Keshari 3 , and John Kurhanewicz 1

1 University of California, San Francisco, San Francisco, CA, United States, 2 Stanford University, CA, United States, 3 Memorial Sloan Kettering Cancer Center, New York, United States

The goal of the current study was to correlate hyperpolarized lactate with the pathologic grade of prostate cancer using living human prostate tissue slices (TSCs) obtained at surgery in a MR compatible 3D tissue culture bioreactor. TSCs obtained from 38 radical prostatectomy patients were studied after injection of hyperpolarized pyruvate and demonstrated that in addition to increased lactate production, high grade prostate cancer had significantly higher lactate efflux. Knowledge of significant extracellular HP lactate in aggressive prostate cancer will be useful for improving interpretation of the in vivo HP signals and interrogated using diffusion weighted HP 13 C MR approaches.

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