Abstract #3841
Hyperpolarized Lactate Production Correlates with Gleason Grade in Patient-Derived Tissues of Prostate Cancer
Renuka Sriram 1 , Mark Van Criekinge 1 , Justin DeLos Santos 1 , Daniel B Vigneron 1 , Robert Bok 1 , Donna Peehl 2 , Kayvan Rahimi Keshari 3 , and John Kurhanewicz 1
1
University of California, San Francisco, San
Francisco, CA, United States,
2
Stanford
University, CA, United States,
3
Memorial
Sloan Kettering Cancer Center, New York, United States
The goal of the current study was to correlate
hyperpolarized lactate with the pathologic grade of
prostate cancer using living human prostate tissue
slices (TSCs) obtained at surgery in a MR compatible 3D
tissue culture bioreactor. TSCs obtained from 38 radical
prostatectomy patients were studied after injection of
hyperpolarized pyruvate and demonstrated that in
addition to increased lactate production, high grade
prostate cancer had significantly higher lactate efflux.
Knowledge of significant extracellular HP lactate in
aggressive prostate cancer will be useful for improving
interpretation of the in vivo HP signals and
interrogated using diffusion weighted HP
13
C
MR approaches.
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