Discriminating low-grade from high-grade peripheral zone prostate cancer by multiparametric MRI: a multicenter study
Marnix C. Maas 1 , Geert J.S. Litjens 1,2 , Alan J. Wright 3 , Masoom A. Haider 4 , Katarzyna J. Macura 5 , Kirsten M. Selns 6 , Daniel J.A. Margolis 7 , Thomas Helbich 8 , Berthold Kiefer 9 , Jurgen J. Ftterer 1 , and Tom W.J. Scheenen 1
Radiology and Nuclear Medicine, Radboud
University Medical Center, Nijmegen, GLD, Netherlands,
Radboud University Medical Center, Nijmegen, GLD,
Research UK Cambridge Institute, University of
Cambridge, Cambridge, United Kingdom,
Health Sciences Center, University of Toronto, Toronto,
H. Morgan Department of Radiology and Radiological
Science, Johns Hopkins University, Baltimore, MD, United
of Circulation and Medical Imaging, Norwegian University
of Science and Technology, Trondheim, Norway,
UCLA David Geffen School of Medicine, Los Angeles, CA,
Imaging and Image-guided Therapy, Medical University
Vienna - General Hospital Vienna, Vienna, Austria,
AG Healthcare, Erlangen, Germany
This study investigates the ability of multiparametric
MRI (mpMRI) including DWI, 1H-MRSI and DCE-MRI to
discriminate low-grade from higher-grade peripheral zone
(PZ) prostate cancer in a multi-center setting, using
whole-mount section histopathology as the gold standard.
Guided by histology and blinded to functional imaging,
ROIs were defined on T2w imaging in PZ tumors in 39
patients from 5 centers, and transferred to functional
parameter maps. ROC analysis resulted in areas under the
curve of 0.800.13 for ADC and 0.830.15 for a
multivariate model including both ADC and MRSI.
Multicenter mpMRI can yield good separation between low
and higher grade PZ tumors.
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