Abstract #3848
Quantitative differentiation of prostate cancer from normal peripheral zone using Magnetic Resonance Fingerprinting (MRF) and Diffusion Mapping
Chaitra Badve 1 , Alice Yu 2 , Shivani Pahwa 3 , Matthew Rogers 2 , Yun Jiang 4 , Yiying Liu 5 , Mark Schluchter 5 , Lee Ponsky 6,7 , Mark Griswold 4 , and Vikas Gulani 1,3
1
Radiology, University Hospitals, Cleveland,
Ohio, United States,
2
School
of Medicine, Case Western Reserve University, Cleveland,
Ohio, United States,
3
Radiology, Case Western
Reserve University, Cleveland, Ohio, United States,
4
Biomedical
Engineering, Case Western Reserve University, Cleveland,
Ohio, United States,
5
Biostatistics,
Case Western Reserve University, Cleveland, Ohio, United
States,
6
Urology,
University Hospitals, Cleveland, Ohio, United States,
7
Urology,
Case Western Reserve University, Cleveland, Ohio, United
States
Magnetic resonance fingerprinting (MRF) was acquired in
patients with clinical suspicion of prostate cancer.
After diagnoses were confirmed by pathology, T1 and T2
values from MRF were used with ADC values to
retrospectively separate malignancy from normal
peripheral zone (NPZ). All MR parameters showed
significant difference between prostate cancer and NPZ.
Furthermore, T2 and ADC used in conjunction had a high
discriminatory power (AUC = 0.996). Further research is
needed to determine the robustness of using T2 and ADC
to identify prostate cancer prospectively, and to
explore the possibly utility of T1 in identifying
malignancy.
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