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Abstract #3855

Clinical Application of 3D High Resolution Multi-shot Diffusion-Weighted MRI in Prostate Cancer Patients undergoing Active Surveillance Protocol for Low-Risk Prostate Cancer

Christopher Nguyen 1,2 , Ali-Reza Sharif-Afshar 3 , Zhaoyang Fan 1 , Sidney Wilson 2 , Xiaoming Bi 4 , Lucas Payor 5 , Rola Saouaf 5 , Hyung Kim 3 , and Debiao Li 1,2

1 Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, 2 Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, 3 Surgery / Urology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4 Siemens Healthcare, Los Angeles, CA, United States, 5 Radiology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

In a small group of prostate cancer patients undergoing active surveillance (AS-PC) patients, a recently developed novel 3D diffusion-prepared multi-shot balanced steady-state free precession technique demonstrated improved suspicious low risk prostate cancer lesion detection compared with single-shot diffusion-weighted echo planar imaging (SS-DW-EPI). We conducted a follow-up study in a significantly larger cohort to further investigate the clinical impact of the proposed technique. The proposed technique continued to yield significantly better lesion detection of biopsy-confirmed lesions compared with SS-DW-EPI. By improving lesion detection, the proposed technique may allow DW MRI to potentially monitor low-risk prostate cancer lesions in AS-PC.

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