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Abstract #3856

Constrained multi-agent tracer-kinetic modeling to assess tumor vascular changes induced by DMXAA treatment

Igor Jacobs 1 , Stefanie Hectors 1 , Gustav Strijkers 1,2 , Klaas Nicolay 1 , and Matthias Schabel 3,4

1 Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3 Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon, United States, 4 Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, United States

Accurate evaluation of antivascular tumor therapies requires detailed analysis of vascular alterations. We have recently proposed a novel multi-agent tracer-kinetic modeling approach for DCE-MRI, which allows simultaneous and self-consistent assessment of blood flow and permeability within one imaging session. In the present study, we have applied this approach to evaluate DMXAA treatment. An early increase in extraction fraction of the dendrimer-based contrast agents and reduced blood flow were simultaneously observed, thereby identifying increased permeability as the main mechanism of DMXAA-induced vascular shutdown, in agreement with literature. This demonstrates the potential of the multi-agent approach to assess therapy-induced vascular changes.

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