Abstract #3857
Micro-vascular effects of photodynamic therapy in tumors evaluated with dynamic contrast-enhanced MRI
Tom Schreurs 1,2 , Stefanie Hectors 1 , Igor Jacobs 1 , Holger Grll 1,3 , Gustav Strijkers 1,2 , and Klaas Nicolay 1
1
Biomedical Engineering, Eindhoven University
of Technology, Eindhoven, Netherlands,
2
Biomedical
Engineering and Physics, Academic Medical Center,
Amsterdam, Netherlands,
3
Oncology
Solutions, Philips Research, Eindhoven, Netherlands
Micro-vascular effects of photodynamic therapy (PDT)
were assessed using Dynamic Contrast Enhanced (DCE) MRI
in a mouse tumor model. PDT is an emerging cancer
therapy based on a light-activated drug. DCE-MRI showed
that tumors were almost completely perfused before PDT,
but partly non-perfused after 1 hour and largely non-perfused
after 24 hours. The results clearly indicated
PDT-induced vascular occlusion. Remaining enhanced
regions coincided with tumor recurrences. This work
shows that DCE-MRI has large potential to monitor PDT
efficacy, early after treatment.
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