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Abstract #3857

Micro-vascular effects of photodynamic therapy in tumors evaluated with dynamic contrast-enhanced MRI

Tom Schreurs 1,2 , Stefanie Hectors 1 , Igor Jacobs 1 , Holger Grll 1,3 , Gustav Strijkers 1,2 , and Klaas Nicolay 1

1 Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, 3 Oncology Solutions, Philips Research, Eindhoven, Netherlands

Micro-vascular effects of photodynamic therapy (PDT) were assessed using Dynamic Contrast Enhanced (DCE) MRI in a mouse tumor model. PDT is an emerging cancer therapy based on a light-activated drug. DCE-MRI showed that tumors were almost completely perfused before PDT, but partly non-perfused after 1 hour and largely non-perfused after 24 hours. The results clearly indicated PDT-induced vascular occlusion. Remaining enhanced regions coincided with tumor recurrences. This work shows that DCE-MRI has large potential to monitor PDT efficacy, early after treatment.

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