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Abstract #3859

Prediction of Treatment Response and Tumor Recurrence Using MR Elastography

Kay Pepin 1 , Steven Ansell 2 , Richard L Ehman 3 , and Kiaran McGee 3

1 Graduate School, Mayo Clinic, Rochester, Minnesota, United States, 2 Hematology, Mayo Clinic, Minnesota, United States, 3 Radiology, Mayo Clinic, Minnesota, United States

Change in tumor mechanical properties measured using MR Elastography may be a biomarker of response to chemotherapy. The ability to determine failure to therapy is a critical function of an imaging biomarker. The results of this animal study demonstrate that MRE is sensitive to an increase in tumor stiffness prior to an increase in tumor volume. Similarly, change in tumor shear stiffness is dose-dependent; the higher the chemotherapy dose the greater the subsequent decrease in tumor stiffness. These results suggest that MRE-derived shear stiffness measurements reflect the observed response to chemotherapy.

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