Prediction of Treatment Response and Tumor Recurrence Using MR Elastography
Kay Pepin 1 , Steven Ansell 2 , Richard L Ehman 3 , and Kiaran McGee 3
Graduate School, Mayo Clinic, Rochester,
Minnesota, United States,
Mayo Clinic, Minnesota, United States,
Mayo Clinic, Minnesota, United States
Change in tumor mechanical properties measured using MR
Elastography may be a biomarker of response to
chemotherapy. The ability to determine failure to
therapy is a critical function of an imaging biomarker.
The results of this animal study demonstrate that MRE is
sensitive to an increase in tumor stiffness prior to an
increase in tumor volume. Similarly, change in tumor
shear stiffness is dose-dependent; the higher the
chemotherapy dose the greater the subsequent decrease in
tumor stiffness. These results suggest that MRE-derived
shear stiffness measurements reflect the observed
response to chemotherapy.
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