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Abstract #3861

Immunocytokine facilitation of natural killer cells accumulation in tumors

Naomi S. Sta Maria 1 , Samuel R. Barnes 1 , David Colcher 2 , Andrew A. Raubitschek 2 , and Russell E. Jacobs 1

1 Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States, 2 Cancer Immunotherapeutics & Tumor Immunology, City of Hope, Duarte, CA, United States

We investigated whether the priming of tumors with immunocytokines can potentiate the accumulation of adoptive human natural killer cells labeled with ferumoxytol, an FDA-approved USPIO, in tumors. We used T2* weighted multi-gradient echo to generate parametric R2* maps of the tumors in NOD-scid-gamma-null mice with human colorectal adenocarcinoma cells, LS-174T.luc. Mice were differentiated into control or immunocytokine treated groups and were imaged pre and post (5hr and 10hr) injection of NK cells. Pretreated mice showed significant increases in tumor R2* values at the 10hr time point. MRI can be used to assess efficacy of adoptive NK cell transfer.

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