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Abstract #3865

DCE-MRI Assessment of Soft-Tissue Sarcoma Response to Preoperative Therapy

Wei Huang 1 , Megan L Holtorf 1 , Aneela Afzal 1 , Yiyi Chen 1 , Brooke R Beckett 1 , and Christopher W Ryan 1

1 Oregon Health & Science University, Portland, OR, United States

Twenty patients with extremity soft-tissue sarcoma who underwent preoperative chemoradiotherapy consented to research DCE-MRI, performed before, after one cycle of chemotherapy, and after completion of therapy before surgery. Ktrans and kep at baseline, after one cycle of therapy, and percent change were much better than RECIST tumor size measurement for early prediction of therapy response. Post-therapy Ktrans, ve, and kep were negatively correlated with necrosis percentage (NP) of the surgical specimen. No significant relationship was observed between post-therapy RECIST and NP.

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