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Abstract #3866

Feasibility of performing weekly intravoxel incoherent motion DW-MRI and monitoring anatomical and functional changes in nasopharynx tumors during chemoradiation therapy

Yonggang Lu 1 , Nancy Lee 1 , Vaois Hatzoglou 1 , Nadeem Riaz 1 , Joseph O. Deasy 1 , and Amita Shukla-Dave 1

1 Memorial Sloan-Kettering Cancer Center, NEW YORK, New York, United States

Our aim is to identify imaging biomarkers predictive of treatment response in nasopharyngeal cancer for personalizing radiotherapy. A total of 37 weekly intravoxel incoherent motion DW-MRI studies were performed on 5 patients to assess early chemoradiation treatment response. The results demonstrated that chemoradiation treatment led to a decrease of tumor volumes in all 5 patients and an increase of diffusion and perfusion metrics in 4 patients. One patient had tumor infiltration of the muscle and the diffusion metric remained unchanged in this patient during treatment. The study concludes that diffusion and perfusion metrics are potential imaging biomarkers of tumor response.

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