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Abstract #3869

Effects of Acquisition Time Variation on DCE-MRI Prediction of Breast Cancer Therapy Response

Andy J Kaempf 1 , Yiyi Chen 1 , Alina Tudorica 1 , Stephen Y-C Chui 1 , Arpana Naik 1 , Karen Y Oh 1 , Nicole Roy 1 , Megan L Troxell 1 , Aneela Afzal 1 , Megan L Holtorf 1 , Mohan Jayatilake 1 , and Wei Huang 1

1 Oregon Health & Science University, Portland, OR, United States

DCE-MRI data with ~10 min acquisition time were collected from 14 breast cancer patients (15 primary tumors) who received neoadjuvant chemotherapy (NACT). Data points were dropped incrementally from the far end of DCE time course to simulate ~9, 8, 7, and 6 min acquisition time. The original and simulated data were subjected to standard and shutter-speed model pharmacokinetic analyses. The results suggest 8 min acquisition time is needed to retain the Ktrans and kep abilities as early predictors of therapy response.

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