Effects of Acquisition Time Variation on DCE-MRI Prediction of Breast Cancer Therapy Response
Andy J Kaempf 1 , Yiyi Chen 1 , Alina Tudorica 1 , Stephen Y-C Chui 1 , Arpana Naik 1 , Karen Y Oh 1 , Nicole Roy 1 , Megan L Troxell 1 , Aneela Afzal 1 , Megan L Holtorf 1 , Mohan Jayatilake 1 , and Wei Huang 1
Oregon Health & Science University,
Portland, OR, United States
DCE-MRI data with ~10 min acquisition time were
collected from 14 breast cancer patients (15 primary
tumors) who received neoadjuvant chemotherapy (NACT).
Data points were dropped incrementally from the far end
of DCE time course to simulate ~9, 8, 7, and 6 min
acquisition time. The original and simulated data were
subjected to standard and shutter-speed model
pharmacokinetic analyses. The results suggest 8 min
acquisition time is needed to retain the Ktrans and kep
abilities as early predictors of therapy response.
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