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Abstract #3868

Spontaneous R2* Fluctuations for Non-Invasive Detection of Cyclic Hypoxia in Head and Neck Squamous Cell Carcinoma Xenografts

Rafal Panek 1 , Lauren C.J. Baker 2 , Liam Welsh 1 , Carol Box 2 , Suzanne A. Eccles 2 , Kate L. Newbold 1 , Kevin J. Harrington 1 , Maria A. Schmidt 1 , Martin O. Leach 1 , and Simon P. Robinson 2

1 Royal Marsden NHS FT and Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Institute of Cancer Research, Sutton, Surrey, United Kingdom

The importance of acutely hypoxic tumour cells, resulting from intermittent tumour blood flow, on tumour progression and radioresistance is recognised. The potential of continuous intrinsic susceptibility MRI measurements of tumour R 2 * to non-invasively detect acute, cyclic hypoxia through changes in the oxy/deoxyhaemoglobin ratio has been previously demonstrated. In this study we have tested the feasibility of measuring spontaneous fluctuations in tumour R 2 * to identify regions with varying erythrocyte or plasma channels flow in head and neck squamous cell carcinoma xenografts on a clinical 3T platform. Additionally, hyperoxia-induced Capital Greek Delta R 2 * and tissue histology were used to spatially confirm hypoxic and perfused tumour regions.

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