Abstract #3872
Evaluating sources of uncertainty on DCE-MRI parameter estimates when using different AIFs
Mihaela Rata 1 , Matthew R Orton 1 , Christina Messiou 1 , Helen Young 2 , Nandita de Souza 1 , David J Collins 1 , and Martin O Leach 1
1
Radiotherapy and Imaging Department, CR-UK
and EPSRC Cancer Imaging Centre, Institute of Cancer
Research and Royal Marsden Hospital, Sutton, Surrey,
United Kingdom,
2
Early
Clinical Development, AstraZeneca, Macclesfield,
Cheshire, United Kingdom
Dynamic contrast-enhanced (DCE) MRI method is a
technique employed in the assessment of tumour response
to novel antiangiogenic therapy. Pharmacokinetic
modelling of such data requires a reliable measure of
the arterial input function (AIF) in order to obtain
robust estimates of physiological parameters
characterising tumour properties. This study explore the
impact on Ktrans estimate of various sources of
uncertainty affecting a MR-DCE acquisition. Three
experiments were performed to separate sources of
uncertainties. The best CoV of measured Ktrans is still
obtained when using a population AIF. A perfect measure
of AIF may yet improve a Ktrans repeatability up to 10%.
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