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Abstract #3872

Evaluating sources of uncertainty on DCE-MRI parameter estimates when using different AIFs

Mihaela Rata 1 , Matthew R Orton 1 , Christina Messiou 1 , Helen Young 2 , Nandita de Souza 1 , David J Collins 1 , and Martin O Leach 1

1 Radiotherapy and Imaging Department, CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 2 Early Clinical Development, AstraZeneca, Macclesfield, Cheshire, United Kingdom

Dynamic contrast-enhanced (DCE) MRI method is a technique employed in the assessment of tumour response to novel antiangiogenic therapy. Pharmacokinetic modelling of such data requires a reliable measure of the arterial input function (AIF) in order to obtain robust estimates of physiological parameters characterising tumour properties. This study explore the impact on Ktrans estimate of various sources of uncertainty affecting a MR-DCE acquisition. Three experiments were performed to separate sources of uncertainties. The best CoV of measured Ktrans is still obtained when using a population AIF. A perfect measure of AIF may yet improve a Ktrans repeatability up to 10%.

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