Abstract #3881
Multi-parametric Longitudinal Study for the Evaluation of Tumor Heterogeneity in Breast Cancer Patients Using Simultaneous MRSI & DWI Techniques
Naranamangalam R Jagannathan 1 , Khushbu Agarwal 1 , Uma Sharma 1 , Smriti Hari 2 , Vurthaluru Seenu 3 , and Rajinder Parshad 3
1
Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India,
2
Department
of Radiodiagnosis, All India Institute of Medical
Sciences, New Delhi, Delhi, India,
3
Department
of Surgical Disciplines, All India Institute of Medical
Sciences, New Delhi, Delhi, India
ChoSNR and ADC were measured from same voxels in
different breast tumor regions (solid tumor, necrosis
and margin) prior to and after III NACT in 11 LABC
patients (6 clinical responders and 5 non-responders).
In responders, increased ChoSNR with decreased ADC of
solid tumor was observed after therapy. ChoSNR decreased
significantly with no ADC change at tumor margin. At
necrosis no change in ChoSNR or ADC was seen. In
non-responders ChoSNR and ADC did not change in tumor
regions. Positive Pearson correlation between ChoSNR and
ADC change signifies combined utility of both techniques
simultaneously in therapeutic management of breast
cancer.
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