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Abstract #3884

Multi-parametric MRI in evaluating pre-and post-menopausal ER positive breast cancer

Elizabeth O'Flynn 1 , David Collins 1 , James D'Arcy 1 , Maria Schmidt 1 , and Nandita deSouza 1

1 CRUK Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom

The purpose of this study was to compare multiparametric MRI parameters of ER positive tumours in pre- and postmenopausal women to assess any differences in tumour functional characteristics and to establish which parameter correlated significantly with response as defined by tumor volume reduction.In premenopausal women with ER positive breast cancer, tumors were larger and more vascular than in postmenopausal women. A rise in the ve correlated significantly with volume reduction in premenopausal women; no specific parameter correlated with response in postmenopausal women.

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