Improved Diagnostic Performance of 3T Breast MRI using Perfusion-Adjusted ADC Values

Diffusion-weighted imaging (DWI) holds potential for reducing false positives on conventional breast MRI based on differences in apparent diffusion coefficient (ADC) values between benign and malignant lesions. However, standard DWI approaches can result in ADC values strongly influenced by perfusion, potentially increasing overlap in ADC between pathologies. In this study, we found that separation of perfusion and diffusion-weighted components of lesion ADC measures using a simplified approach can improve diagnostic performance. Furthermore, we found that a multiparametric combination of DWI and DCE features can provide more accurate assessment of suspicious MRI-detected breast lesions.

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