Abstract #3890
Improved Diagnostic Performance of 3T Breast MRI using Perfusion-Adjusted ADC Values
Niloufar Fozouni 1 , Cheng-Liang Liu 1 , Habib Rahbar 1 , Constance D Lehman 1 , and Savannah C Partridge 1
1
Department of Radiology, University of
Washington, Seattle, Washington, United States
Diffusion-weighted imaging (DWI) holds potential for
reducing false positives on conventional breast MRI
based on differences in apparent diffusion coefficient
(ADC) values between benign and malignant lesions.
However, standard DWI approaches can result in ADC
values strongly influenced by perfusion, potentially
increasing overlap in ADC between pathologies. In this
study, we found that separation of perfusion and
diffusion-weighted components of lesion ADC measures
using a simplified approach can improve diagnostic
performance. Furthermore, we found that a
multiparametric combination of DWI and DCE features can
provide more accurate assessment of suspicious
MRI-detected breast lesions.
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