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Abstract #3891

Intravoxel incoherent motion MRI may reveal microvascular variation of fibroglandular tissues in breast cancer

Jing Yuan 1 , Gladys G. Lo 2 , Oi Lei Wong 1 , Helen H.L. Chan 2 , Abby Y. Ding 1 , Ting Ting Wong 3 , and Polly S.Y. Cheung 3

1 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, China, 2 Department of Diagnostic & Interventional Radiology, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, China, 3 Breast Care Center, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, China

This study aims to investigate the micro-vascularity of fibroglandular tissues (FGTs) in breast cancer (BC) using intravoxel incoherent motion (IVIM) MRI. 21 histology-confirmed patients received IVIM-MRI at 3T. True diffusion D, pseudo-diffusion D*, pseudo-diffusion fraction f and ADC in ipsilateral and contralateral breast FGTs were compared. Results show that FGT D* and f in the ipsilateral tumor-bearing breast were higher than those in the contralateral breast (D*: 24.969.3710 -3 mm 2 /s v.s. 19.989.3710 -3 mm 2 /s; f: 0.1230.034 v.s. 0.1090.030), with D* being significant (p=0.033). FGT microvascular variation revealed by IVIM-MRI may potentially be used for breast cancer risk assessment, characterization and/or prognosis

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