Abstract #3892
Intralesional Characteristics of Correlated 18-Fluorodeoxyglucose PET and Intravoxel Incoherent Motion Parameters in Locally Advanced Breast Cancer
Jason Ostenson 1 , Linda Moy 1 , Sungheon G. Kim 1 , Amy Melsaether 1 , Komal Jhaveri 2 , Christian Geppert 3 , David Faul 3 , Francisco Esteva 2 , Sylvia Adams 2 , Freya Schnabel 4 , Kimberly Jackson 1 , Joon Lee 1 , Christopher Glielmi 3 , Gene Young Cho 1,5 , Thorsten Feiweier 6 , and Eric E. Sigmund 1
1
Department of Radiology, NYU Langone Medical
Center, New York, NY, United States,
2
Perlmutter
Cancer Center, NYU Langone Medical Center, New York, NY,
United States,
3
Siemens
Medical Solutions, New York, NY, United States,
4
Department
of Surgery, NYU Langone Medical Center, New York, NY,
United States,
5
Sackler Institute of Graduate
Biomedical Sciences, NYU School of Medicine, New York,
NY, United States,
6
Siemens
AG, Erlangen, Germany
Simultaneously acquired diffusion weighted imaging and
18-fluorodeoxyglucose(FDG)-PET are employed to explore
the relationship between glucose avidity, diffusion, and
perfusion in breast cancer. Intravoxel incoherent motion
metrics are calculated and combined with correlated FDG-PET
standard uptake values (SUV) for all voxels in 16
histopathologically proven breast cancer lesions.
Two-dimensional histograms and Pearsons correlations
are used to define three lesion types. Each lesions
voxels are separated into three groups according to
their SUV, diffusion, and perfusion fraction. The
results yield insight into the heterogeneity of the
tumor microenvironment and show significant correlations
with estrogen receptor expression and a cellular
proliferation marker (Ki-67).
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