Meeting Banner
Abstract #3892

Intralesional Characteristics of Correlated 18-Fluorodeoxyglucose PET and Intravoxel Incoherent Motion Parameters in Locally Advanced Breast Cancer

Jason Ostenson 1 , Linda Moy 1 , Sungheon G. Kim 1 , Amy Melsaether 1 , Komal Jhaveri 2 , Christian Geppert 3 , David Faul 3 , Francisco Esteva 2 , Sylvia Adams 2 , Freya Schnabel 4 , Kimberly Jackson 1 , Joon Lee 1 , Christopher Glielmi 3 , Gene Young Cho 1,5 , Thorsten Feiweier 6 , and Eric E. Sigmund 1

1 Department of Radiology, NYU Langone Medical Center, New York, NY, United States, 2 Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, United States, 3 Siemens Medical Solutions, New York, NY, United States, 4 Department of Surgery, NYU Langone Medical Center, New York, NY, United States, 5 Sackler Institute of Graduate Biomedical Sciences, NYU School of Medicine, New York, NY, United States, 6 Siemens AG, Erlangen, Germany

Simultaneously acquired diffusion weighted imaging and 18-fluorodeoxyglucose(FDG)-PET are employed to explore the relationship between glucose avidity, diffusion, and perfusion in breast cancer. Intravoxel incoherent motion metrics are calculated and combined with correlated FDG-PET standard uptake values (SUV) for all voxels in 16 histopathologically proven breast cancer lesions. Two-dimensional histograms and Pearsons correlations are used to define three lesion types. Each lesions voxels are separated into three groups according to their SUV, diffusion, and perfusion fraction. The results yield insight into the heterogeneity of the tumor microenvironment and show significant correlations with estrogen receptor expression and a cellular proliferation marker (Ki-67).

This abstract and the presentation materials are available to members only; a login is required.

Join Here