Abstract #3903
Deep Anesthesia Provokes Dissimilar Resting State Connectivities in ADHD Rat Model and Normal Control
Sheng-Min Huang 1 , Wei-Cheng Lee 1 , Kung-Chu Ho 2 , and Fu-Nien Wang 1
1
Department of Biomedical Engineering &
Environmental Sciences, National Tsing Hua University,
Hsinchu, Taiwan,
2
Nuclear
Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
In this abstract the resistance to isoflurane anesthesia
between ADHD model (SHR) and normal control (WKY) was
compared by using resting state functional MRI. A
different distribution of remaining network under high
dose anesthesia was found. WKY group tends to preserve
the frontal region of brain, while SHR group keep the
central region. Since we can speculate that the
connections in high anesthesia level are very
fundamental networks, these basic differences between
SHR and WKY may be one of the origins of functional
abnormality in ADHD rat.
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