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Abstract #3902

Anesthesia level modulate brain activity and connections in Monkey

Zhentao Zuo 1 , Xudong Zhao 1 , Yifan Miao 2 , Shuo Shen 1 , Zuxiang Liu 1 , and Yuanye Ma 1

1 Chinese Academy of Sciences, Institute of Biophysics, Beijing, Beijing, China, 2 State Key lab of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, Beijing, China

Resting state-fMRI (rs-fMRI) allows studying aesthesis status through functional connectivity (FC) and amplitude low-frequency fluctuation (ALFF), as well as the mechanisms of different neurological diseases. Several monkeys scanner with different anesthesia depths underlying rs-fMRI were scanned to explore the variation of the monkey brain FC patterns and brain region neuron fluctuation. We found different drip concentrations will affect the monkey anesthesia depth. Higher concentration suppresses more neurons activity and also decreases the connections between different cerebral hemispheres and surround regions. It also opened a new method to explore how the intrinsic network created, and whether the connectome dependent on the neuron activity.

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