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Abstract #3901

Default Mode Network Abnormality in ADHD Rat Model

Sheng-Min Huang 1 , Wei-Cheng Lee 1 , Kung-Chu Ho 2 , and Fu-Nien Wang 1

1 Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2 Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Resting state functional MRI is an emerging neuroimaging method, examining the connectivity of brain neural circuits. In this work a seed-based analysis was carried out to compare the resting state network between normal (WKY) and ADHD rat model (SHR). Results show that ADHD rat presented a network contains caudate putamen region but WKY didn't. This difference may be tied to the symptoms of ADHD since putamen is involved in the regulation of motor behavior and caudate nucleus is related to social behavior.

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