Abstract #3900
Neurophysiological and neuroenergetic basis of spontaneous BOLD signal fluctuations in resting-state fMRI connectivity maps
Peter Herman 1 , Basavaraju G. Sanganahalli 1 , Daniel Coman 1 , Hal Blumenfeld 2 , Lihong Jiang 1 , Douglas L. Rothman 1,3 , and Fahmeed Hyder 1,3
1
Diagnostic Radiology, Yale University, New
Haven, Connecticut, United States,
2
Neurobiology,
Yale University, New Haven, Connecticut, United States,
3
Biomedical
Engineering, Yale University, New Haven, Connecticut,
United States
Resting-state fMRI (R-fMRI) is powerful for mapping
networks. Since oscillations in metabolic/neural events
are linked to R-fMRI networks and studies suggest that
absolute metabolic/neural baseline interacts with
evoked/spontaneous signals, we measured blood flow,
neural activity, glucose oxidation, glutamatergic
neurotransmission, and BOLD in relation to two states.
Fluctuations in metabolic/neural activities underlying
connectivity maps, regardless of the state, represented
at most 5% of the total baseline metabolic/neural level.
Functional correlation density (FCD) maps, not
seed-based correlation maps, showed significant
alteration between the states in accord with other
absolute measures of states, signifying the importance
of FCD and absolute baseline in R-fMRI.
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