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Abstract #3900

Neurophysiological and neuroenergetic basis of spontaneous BOLD signal fluctuations in resting-state fMRI connectivity maps

Peter Herman 1 , Basavaraju G. Sanganahalli 1 , Daniel Coman 1 , Hal Blumenfeld 2 , Lihong Jiang 1 , Douglas L. Rothman 1,3 , and Fahmeed Hyder 1,3

1 Diagnostic Radiology, Yale University, New Haven, Connecticut, United States, 2 Neurobiology, Yale University, New Haven, Connecticut, United States, 3 Biomedical Engineering, Yale University, New Haven, Connecticut, United States

Resting-state fMRI (R-fMRI) is powerful for mapping networks. Since oscillations in metabolic/neural events are linked to R-fMRI networks and studies suggest that absolute metabolic/neural baseline interacts with evoked/spontaneous signals, we measured blood flow, neural activity, glucose oxidation, glutamatergic neurotransmission, and BOLD in relation to two states. Fluctuations in metabolic/neural activities underlying connectivity maps, regardless of the state, represented at most 5% of the total baseline metabolic/neural level. Functional correlation density (FCD) maps, not seed-based correlation maps, showed significant alteration between the states in accord with other absolute measures of states, signifying the importance of FCD and absolute baseline in R-fMRI.

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