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Abstract #3933

Impaired cerebrovascular in obese children with obstructive sleep apnea compared to healthy controls

Junseok Kim 1,2 , Jackie Leung 2 , Indra Narang 2 , Paula Louise Croal 2 , and Andrea Kassner 1,2

1 University of Toronto, Toronto, ON, Canada, 2 Hospital for Sick Children, Toronto, ON, Canada

Obesity is the most common cause of obstructive sleep apnea (OSA) in children. With childhood obesity at epidemic levels, the incidence of OSA is rising. OSA is characterized by intermittent episodes of nocturnal hypoxia, hypercapnia and sleep disruption. Moreover, intermittent hypoxia leads to oxidative damage of the endothelial cells, resulting in endothelial dysfunction which compromises vasodilatory capacity. Reduction in vasodilatory capacity can be quantified experimentally using MR-based cerebrovascular reactivity (CVR). We found that obese children with OSA have reduced CVR, both globally and regionally, compared to controls with no OSA.

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