Abstract #3933
Impaired cerebrovascular in obese children with obstructive sleep apnea compared to healthy controls
Junseok Kim 1,2 , Jackie Leung 2 , Indra Narang 2 , Paula Louise Croal 2 , and Andrea Kassner 1,2
1
University of Toronto, Toronto, ON, Canada,
2
Hospital
for Sick Children, Toronto, ON, Canada
Obesity is the most common cause of obstructive sleep
apnea (OSA) in children. With childhood obesity at
epidemic levels, the incidence of OSA is rising. OSA is
characterized by intermittent episodes of nocturnal
hypoxia, hypercapnia and sleep disruption. Moreover,
intermittent hypoxia leads to oxidative damage of the
endothelial cells, resulting in endothelial dysfunction
which compromises vasodilatory capacity. Reduction in
vasodilatory capacity can be quantified experimentally
using MR-based cerebrovascular reactivity (CVR). We
found that obese children with OSA have reduced CVR,
both globally and regionally, compared to controls with
no OSA.
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