Stability of tissue model parameters: Using the full analytical solution or the asymptotic approximation?

The oxygen extraction fraction is of great clinical interest providing a biomarker for brain tissue viability and a parameter for the evaluation of diseases such as tumor, stroke, and Alzheimers disease. The analytical tissue model in the static dephasing regime has facilitated promising in-vivo results mapping hemodynamic parameters such as the OEF and the venous blood volume fraction separately using MRI. This work shows a comparison between the fit results using the full analytical model and the more frequently used asymptotic approximation in terms of accuracy and precision based on Monte-Carlo simulations and robustness in-vivo.

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