Separating the magnitude and temporal responses in a BOLD-based CO2 hypercapnia leads to improved inter-session reliability as well as characterization of hemodynamic impairment: a clinical multi-cohort study

Hypercapnia-induced cerebrovascular reactivity is a powerful tool to study the ability of the brains blood vessels to vasodilate. The clinical utility of CVR has been demonstrated in multiple applications. There are however continued efforts to improve the CVR time-series analysis. In this study we introduce a deconvolution approach that produces a vascular transfer function, which can be calculated by tissue type or at a voxel-wise level. We found this approach had higher sensitivity to patient group differences in white matter, compared to conventional CVR, and therefore may be useful as an adjunct approach.

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