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Abstract #3936

Regional and state-dependent properties of M for high-field calibrated fMRI in rat brain

Christina Y. Shu 1 , Daniel Coman 2 , Basavaraju G. Sanganahalli 2 , Helen Wang 2 , Christoph Juchem 2 , Peter Herman 2 , and Fahmeed Hyder 1,2

1 Biomedical Engineering, Yale University, New Haven, CT, United States, 2 Diagnostic Radiology, Yale University, CT, United States

In calibrated fMRI the BOLD signal range from deoxyhemoglobin to oxyhemoglobin is reflected by M. Since blood oxygenation changes are captured with relaxation rates by gradient echo (R2*) and spin echo (R2), M is echo time multiplied by R2 (i.e., R2*- R2). Because it is unclear if the M range reported in calibrated fMRI studies is due to regional/state differences, we tested M estimated from R2 in rat brain. Homogenous M values were found in the cortex regardless of the brain state. These results suggest that a direct R2 mapping method may provide more accurate M values for calibrated fMRI.

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