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Abstract #3937

Quantitative mapping for high-field calibrated fMRI in rat brain

Christina Y. Shu 1 , Douglas Rothman 1,2 , Basavaraju G. Sanganahalli 2 , Daniel Coman 2 , Peter Herman 2 , and Fahmeed Hyder 1,2

1 Biomedical Engineering, Yale University, New Haven, CT, United States, 2 Diagnostic Radiology, Yale University, New Haven, CT, United States

In calibrated fMRI the power-law relationship between the BOLD signal with blood flow and oxygen consumption is quantified by the parameter β. The frequently used β value of 1.5 comes from simulation results. To make calibrated fMRI independent of assumptions and hence applicable for clinical settings, we developed a method for β mapping by measuring R2, the most sensitive relaxation component of BOLD signal, as a function of intravascular susceptibility weighting. Since we measured lower β values in cortex than previously assumed and observed β heterogeneities across other regions, there is need for reevaluation of physiological parameters for calibrated fMRI.

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