Abstract #3937
Quantitative mapping for high-field calibrated fMRI in rat brain
Christina Y. Shu 1 , Douglas Rothman 1,2 , Basavaraju G. Sanganahalli 2 , Daniel Coman 2 , Peter Herman 2 , and Fahmeed Hyder 1,2
1
Biomedical Engineering, Yale University, New
Haven, CT, United States,
2
Diagnostic
Radiology, Yale University, New Haven, CT, United States
In calibrated fMRI the power-law relationship between
the BOLD signal with blood flow and oxygen consumption
is quantified by the parameter β. The frequently used β
value of 1.5 comes from simulation results. To make
calibrated fMRI independent of assumptions and hence
applicable for clinical settings, we developed a method
for β mapping by measuring R2, the most sensitive
relaxation component of BOLD signal, as a function of
intravascular susceptibility weighting. Since we
measured lower β values in cortex than previously
assumed and observed β heterogeneities across other
regions, there is need for reevaluation of physiological
parameters for calibrated fMRI.
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