Abstract #3948
Aberrant Brain Resting-State Functional Connectivity in Patients with Obstructive Sleep Apnea
Bumhee Park 1 , Jose A Palomares 1 , Mary A Woo 2 , Daniel W Kang 3 , Paul M Macey 2 , Frisca L Yan-Go 4 , Ronald M Harper 5 , and Rajesh Kumar 1,6
1
Anesthesiology, University of California at
Los Angeles, Los Angeles, CA, United States,
2
School
of Nursing, University of California at Los Angeles, Los
Angeles, CA, United States,
3
Medicine,
University of California at Los Angeles, Los Angeles,
CA, United States,
4
Neurology,
University of California at Los Angeles, Los Angeles,
CA, United States,
5
Neurobiology,
University of California at Los Angeles, Los Angeles,
CA, United States,
6
Radiological
Sciences, University of California at Los Angeles, Los
Angeles, CA, United States
OSA subjects show impaired autonomic, affective,
executive, sensori-motor, and cognitive functions. Brain
injury, assessed by various MRI procedures, appears in
multiple sites regulating these functions; however, the
integrity of functional networks remains unclear. We
examined resting functional interactions and complex
network organization across the whole-brain in OSA over
controls and found aberrant functional connections and
altered brain network organization in those regions. The
findings suggest that impaired functions in OSA may stem
from altered functional connectivity and brain network
organization. The outcomes likely result from prominent
structural brain changes in both axons and nuclear
structures reported-earlier.
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