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Abstract #3949

Development of the relationship between the Default Mode Network and frontal task-positive areas in preterm newborns: a RS-fMRI study.

Elisa Marchetta 1,2 , Sara Cirillo 1 , Pasquale Della Rosa 3 , Silvia Pontesilli 1 , Andrea Falini 1,4 , Graziano Barera 5 , Cristina Baldoli 1,4 , and Paola Scifo 6,7

1 Neuroradiology Dept., San Raffaele Hospital, Milan, -, Italy, 2 University of Milano-Bicocca, Milan, -, Italy, 3 Institute of Molecular Bioimaging and Physiology, CNR, Segrate, -, Italy, 4 Vita-Salute San Raffaele University, Milan, -, Italy, 5 Division of Neonatology, Pediatrics Dept, San Raffaele Hospital, Milan, -, Italy, 6 Nuclear Medicine Dept., San Raffaele Hospital, Milan, -, Italy, 7 CERMAC, San Raffaele Hospital, Milan, -, Italy

The brain functional architecture grows fast during prenatal period. This study aims to investigate the development of DMN and its correlation with frontal task-positive areas by means of Resting State fMRI in a group of healthy preterm newborns. Interestingly, we found significant correlations between mPFC and the frontopolar region. This functional association was also found to be significantly correlated with age. Our results suggest that the recruitment of regions involved in high order functions might start since the very early age, although frontal areas are characterized by late myelination and expected late connectivity.

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