Abstract #3949
Development of the relationship between the Default Mode Network and frontal task-positive areas in preterm newborns: a RS-fMRI study.
Elisa Marchetta 1,2 , Sara Cirillo 1 , Pasquale Della Rosa 3 , Silvia Pontesilli 1 , Andrea Falini 1,4 , Graziano Barera 5 , Cristina Baldoli 1,4 , and Paola Scifo 6,7
1
Neuroradiology Dept., San Raffaele Hospital,
Milan, -, Italy,
2
University
of Milano-Bicocca, Milan, -, Italy,
3
Institute
of Molecular Bioimaging and Physiology, CNR, Segrate, -,
Italy,
4
Vita-Salute
San Raffaele University, Milan, -, Italy,
5
Division
of Neonatology, Pediatrics Dept, San Raffaele Hospital,
Milan, -, Italy,
6
Nuclear
Medicine Dept., San Raffaele Hospital, Milan, -, Italy,
7
CERMAC,
San Raffaele Hospital, Milan, -, Italy
The brain functional architecture grows fast during
prenatal period. This study aims to investigate the
development of DMN and its correlation with frontal
task-positive areas by means of Resting State fMRI in a
group of healthy preterm newborns. Interestingly, we
found significant correlations between mPFC and the
frontopolar region. This functional association was also
found to be significantly correlated with age. Our
results suggest that the recruitment of regions involved
in high order functions might start since the very early
age, although frontal areas are characterized by late
myelination and expected late connectivity.
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