Altered resting state functional connectivity in hypothyroidism
Subash Khushu 1 , Sadhana Singh 1 , Mukesh Kumar 1 , Shilpi Modi 1 , Prabhjot Kaur 1 , and L Ravi Shankar 2
NMR Research Centre, INMAS, DRDO, Delhi,
Research Centre, INMAS, DRDO, Delhi, Delhi, India
Hypothyroidism affects brain functioning as suggested by
various neuroimaging studies. The primary focus of this
study was to examine whether hypothyroidism would impact
connectivity among resting state networks with the use
of resting-state fMRI. Our results showed significantly
decreased functional connectivity in the region of right
fronto-parietal network, medial visual network and motor
network in hypothyroid patients as compared with healthy
controls. These findings suggest dysfunction of motor
and cognitive functions in hypothyroidism.
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