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Abstract #3953

Altered resting state functional connectivity in hypothyroidism

Subash Khushu 1 , Sadhana Singh 1 , Mukesh Kumar 1 , Shilpi Modi 1 , Prabhjot Kaur 1 , and L Ravi Shankar 2

1 NMR Research Centre, INMAS, DRDO, Delhi, Delhi, India, 2 Thyroid Research Centre, INMAS, DRDO, Delhi, Delhi, India

Hypothyroidism affects brain functioning as suggested by various neuroimaging studies. The primary focus of this study was to examine whether hypothyroidism would impact connectivity among resting state networks with the use of resting-state fMRI. Our results showed significantly decreased functional connectivity in the region of right fronto-parietal network, medial visual network and motor network in hypothyroid patients as compared with healthy controls. These findings suggest dysfunction of motor and cognitive functions in hypothyroidism.

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