Abstract #3954
Functional connectivity MRI can distinguish experimental pain from the resting state with seed ROI in the posterior insula, but not the anterior insula
Keith M Vogt 1 and James W Ibinson 2
1
Anesthesiology, University of Pittsburgh
Medical Center, Pittsburgh, PA, United States,
2
Center
for Pain Research, Dept of Anesthesiology, University of
Pittsburgh, Pittsburgh, PA, United States
The portion of the insula chosen as the seed region for
functional connectivity MRI (fcMRI) analysis can
dramatically affect the resulting maps. This is
particularly important when comparing maps obtained
during rest to those during experimental pain. In this
fcMRI study, seed region analyses revealed that the
difference maps for posterior insula Pain vs Rest
connectivity was obviously different than those seen
with an anterior insular seed region. Thus, the
posterior insula is a putative brain area for
differentiating the experience of acute pain from rest,
while the anterior insula does not exhibit this
specificity.
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