Abstract #3957
Dynamic changes in whole-brain functional connectivity during story listening
Gloria Castellazzi 1,2 , Fulvia Palesi 2,3 , Ahmed T. Toosy 4 , Stefania Bruno 5 , Egidio D'Angelo 2,6 , and Claudia A.M. Wheeler-Kingshott 7
1
Department of Electrical, Computer and
Biomedical Engineering, University of Pavia, Pavia, PV,
Italy,
2
Brain
Connectivity Center, C. Mondino National Neurological
Institute, Pavia, PV, Italy,
3
Department
of Physics, University of Pavia, Pavia, PV, Italy,
4
Department
of Brain Repair and Rehabilitation, Queen Square MS
Centre, UCL Institute of Neurology, London, England,
United Kingdom,
5
Overdale
Hospital, Jersey, England, United Kingdom,
6
Department
of Brain and Behavioral Sciences, University of Pavia,
Pavia, PV, Italy,
7
NMR
Research Unit, Department of Neuroinflammation, Queen
Square MS Centre, UCL Institute of Neurology, London,
England, United Kingdom
During complex continuous cognitive tasks, the brain
elaborates information over multiple domains and time
scales. These operations contribute to dynamically
shape, over space and time, the whole-brain functional
connectivity. We used rs-fMRI to investigate the changes
in brain functional connectivity occurring in subjects
listening to a narrated story. Results show that the
listening task dynamically alters the shape of the
functional connectome in a non-random way, affecting
sensory prior that cognitive brain networks. A possible
interpretation looks at the brain as a prediction
engine that constantly generates predictions about the
optimal configuration of the networks to process the
impending input.
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