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Abstract #3957

Dynamic changes in whole-brain functional connectivity during story listening

Gloria Castellazzi 1,2 , Fulvia Palesi 2,3 , Ahmed T. Toosy 4 , Stefania Bruno 5 , Egidio D'Angelo 2,6 , and Claudia A.M. Wheeler-Kingshott 7

1 Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, PV, Italy, 2 Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, PV, Italy, 3 Department of Physics, University of Pavia, Pavia, PV, Italy, 4 Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 5 Overdale Hospital, Jersey, England, United Kingdom, 6 Department of Brain and Behavioral Sciences, University of Pavia, Pavia, PV, Italy, 7 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom

During complex continuous cognitive tasks, the brain elaborates information over multiple domains and time scales. These operations contribute to dynamically shape, over space and time, the whole-brain functional connectivity. We used rs-fMRI to investigate the changes in brain functional connectivity occurring in subjects listening to a narrated story. Results show that the listening task dynamically alters the shape of the functional connectome in a non-random way, affecting sensory prior that cognitive brain networks. A possible interpretation looks at the brain as a prediction engine that constantly generates predictions about the optimal configuration of the networks to process the impending input.

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