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Abstract #3965

Functional connectivity assessment using R2* resting-state functional MRI

Venkata Veerendra Nadh Chebrolu 1 , Suresh Joel 1 , Brice Fernandez 2 , Ek Tsoon Tan 3 , Luca Marinelli 3 , Dattesh Shanbhag 1 , Radhika Madhavan 1 , Rachel Connett 4 , Ajit Shankaranarayanan 4 , and John Schenck 5

1 Medical Image Analysis Lab, GE Global Research, Bangalore, Karnataka, India, 2 GE Healthcare, Muenchen, Germany, 3 MRI Laboratory, GE Global Research, NY, United States, 4 GE Healthcare, CA, United States, 5 MRI Technologies & Systems, GE Global Research, NY, United States

In recent years, resting state functional connectivity (rs-FC) has been widely used to image brain function. rs-FC is measured by correlation of blood oxygen level dependent (BOLD) MRI signal time-courses. BOLD signal has contributions from cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral metabolic oxygen rate (CMRO2). The initial magnetization (M) is associated with CBF and CBV. Transverse relaxation rate (R2*) is associated with CMRO2, which is related more specifically with neuronal activity than CBF and CBV. In this work, we estimate functional connectivity using R2* time-courses and compare the results with conventional BOLD rs-fMRI.

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