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Abstract #3966

3D Hybrid Radial-Cartesian Sampling for Improved Resting State FMRI using k-t FASTER

Mark Chiew 1 , Nadine N Graedel 1 , Jennifer A McNab 2 , Stephen M Smith 1 , and Karla L Miller 1

1 FMRIB Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Radiology, Stanford University, California, United States

In this work, the k-t FASTER method for accelerating resting state FMRI data acquisition is demonstrated using a 3D hybrid radial-Cartesian acquisition, which facilitates accelerated reconstruction at multiple temporal resolutions. We combine k-t FASTER acceleration with parallel imaging, using radial acceleration factors ranging from R=1.67 to R=12.5x to produce 2 mm isotropic whole brain images at TRs ranging from 3 s down to 0.4 s. Resting state network expression is found to be optimised when the benefit of increased temporal degrees of freedom (provided by higher acceleration), is offset by diminishing reconstruction quality.

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