Abstract #3972
Intratracheal manganese-enhanced MRI (MEMRI) at very low dose: an effective approach for lung tumor detection
Andrea Bianchi 1 , Oliviero G. Gobbo 2 , Sandrine Dufort 3 , Lucie Sancey 4 , Franois Lux 4 , Olivier Tillement 4 , Jean-Luc Coll 3 , and Yannick Crmillieux 1
1
Centre de Rsonance Magntique des Systmes
Biologiques, University of Bordeaux, Bordeaux, Bordeaux,
France,
2
Trinity
College Dublin, School of Biochemistry and Immunology,
Dublin, Ireland,
3
IAB-INSERM,
UJF U 823, Grenoble, France,
4
ILM
UMR 5306, University Lyon 1, Lyon, France
The small hydrodynamic diameter, high water solubility,
large availability on the market and the reduced cost of
manganese (Mn2+) compounds make MEMRI a good candidate
for oncological applications. We present here for the
first time an in vivo MRI study of lung cancer detection
in tumor-bearing mice using very low doses of
intratracheally- and intravenously- administered
manganese chloride (MnCl2). The localization of the
tumors was validated against bioluminescence imaging
(BLI) and histology. Due to the possible neurotoxicity
of the manganese, the accumulation of MnCl2 in the brain
was evaluated using MRI.
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