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Abstract #3972

Intratracheal manganese-enhanced MRI (MEMRI) at very low dose: an effective approach for lung tumor detection

Andrea Bianchi 1 , Oliviero G. Gobbo 2 , Sandrine Dufort 3 , Lucie Sancey 4 , Franois Lux 4 , Olivier Tillement 4 , Jean-Luc Coll 3 , and Yannick Crmillieux 1

1 Centre de Rsonance Magntique des Systmes Biologiques, University of Bordeaux, Bordeaux, Bordeaux, France, 2 Trinity College Dublin, School of Biochemistry and Immunology, Dublin, Ireland, 3 IAB-INSERM, UJF U 823, Grenoble, France, 4 ILM UMR 5306, University Lyon 1, Lyon, France

The small hydrodynamic diameter, high water solubility, large availability on the market and the reduced cost of manganese (Mn2+) compounds make MEMRI a good candidate for oncological applications. We present here for the first time an in vivo MRI study of lung cancer detection in tumor-bearing mice using very low doses of intratracheally- and intravenously- administered manganese chloride (MnCl2). The localization of the tumors was validated against bioluminescence imaging (BLI) and histology. Due to the possible neurotoxicity of the manganese, the accumulation of MnCl2 in the brain was evaluated using MRI.

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