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Abstract #3973

Evaluation of a novel whole lung 3D dynamic OE-MRI protocol in healthy subjects

Jose L Ulloa 1,2 , Alexandra R Morgan 1,2 , and Geoff JM Parker 1,2

1 Bioxydyn Ltd, Manchester, United Kingdom, 2 Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom

Dynamic oxygen-enhanced MRI (dOEMRI) provides imaging biomarkers of regional lung ventilation and perfusion. However, time sampling constraints have limited it to single slice imaging. In this work, we evaluate a novel quantitative whole lung 3D dOEMRI protocol based on a standard single-shot 3D MPRAGE sequence. Sequence parameters were optimised to maximise contrast in the lung when switching from air to O 2 . The protocol enables the capture of the whole lung volume within a breathing cycle. Six healthy volunteers were scanned twice, one week apart. The protocol shows reproducible T1 measurements and allows characterisation of dynamic ΔpO 2 .

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