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Abstract #3974

High-resolution ZTE MR imaging of emphysematous lungs in rats

Andrea Bianchi 1 , Marta Tibiletti 2 , David Kind 1 , Andrea Vgtle 1 , Michael Neumaier 1 , Thomas Kaulisch 1 , Volker Rasche 2 , and Detlef Stiller 1

1 Targeting Discovery Research, In vivo imaging laboratory, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Baden-Wrttemberg, Germany, 2 Core Facility Small Animal MRI, Ulm University, Baden-Wrttemberg, Germany

One of the main open issues in pre-clinical lung imaging is how to provide full coverage of the lung while keeping good image quality in a reasonable acquisition time, with both high spatial resolution and significant signal-to-noise ratio (SNR) in lung parenchyma. We propose here for the first time the investigation of an emphysema model in rats using a ZTE sequence and a thorax-optimized phased-array coil. The results were validated against the gold-standard micro-CT and the standard measurement of T2* using ultra-short echo time (UTE) MRI.

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