Abstract #3974
High-resolution ZTE MR imaging of emphysematous lungs in rats
Andrea Bianchi 1 , Marta Tibiletti 2 , David Kind 1 , Andrea Vgtle 1 , Michael Neumaier 1 , Thomas Kaulisch 1 , Volker Rasche 2 , and Detlef Stiller 1
1
Targeting Discovery Research, In vivo
imaging laboratory, Boehringer Ingelheim Pharma GmbH &
Co. KG, Biberach an der Riss, Baden-Wrttemberg,
Germany,
2
Core
Facility Small Animal MRI, Ulm University,
Baden-Wrttemberg, Germany
One of the main open issues in pre-clinical lung imaging
is how to provide full coverage of the lung while
keeping good image quality in a reasonable acquisition
time, with both high spatial resolution and significant
signal-to-noise ratio (SNR) in lung parenchyma. We
propose here for the first time the investigation of an
emphysema model in rats using a ZTE sequence and a
thorax-optimized phased-array coil. The results were
validated against the gold-standard micro-CT and the
standard measurement of T2* using ultra-short echo time
(UTE) MRI.
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