Dual-nuclei 19 F- 1 H MRI for studying administration and clearance of perfluorooctane in rat lungs
Maya Khalif 1 , Hongchen Wang 1 , Lizheng Qiu 1 , Catherine Sebri 1 , and Ludovic De Rochefort 1
IR4M (Imagerie par Rsonance Magntique
Mdicale et Multi-Modalits), Universit Paris-Sud,
CNRS, UMR8081, Orsay, France
Total Liquid Ventilation (TLV) has been investigated as
a medium for gas transport and diffusion. It has been
used with perfluocarbons (PFCs), with perfluorooctane
(PFOC) in particular, which showed good tolerance in
vivo. To follow PFOC administration and clearance in rat
lungs, we used dual-nuclei MRI and MRS with a home-build
double-resonant coil. PFOC kinetics and clearance times
are presented in this work.
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