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Abstract #3982

Dual-nuclei 19 F- 1 H MRI for studying administration and clearance of perfluorooctane in rat lungs

Maya Khalif 1 , Hongchen Wang 1 , Lizheng Qiu 1 , Catherine Sebri 1 , and Ludovic De Rochefort 1

1 IR4M (Imagerie par Rsonance Magntique Mdicale et Multi-Modalits), Universit Paris-Sud, CNRS, UMR8081, Orsay, France

Total Liquid Ventilation (TLV) has been investigated as a medium for gas transport and diffusion. It has been used with perfluocarbons (PFCs), with perfluorooctane (PFOC) in particular, which showed good tolerance in vivo. To follow PFOC administration and clearance in rat lungs, we used dual-nuclei MRI and MRS with a home-build double-resonant coil. PFOC kinetics and clearance times are presented in this work.

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