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Abstract #3983

Second-Order Texture Analysis of Hyperpolarized 3 He MRI - Beyond the Ventilation Defect

Damien Pike 1,2 , Dante Capaldi 1,2 , Sarah Ashley Mattonen 2 , Fumin Guo 1,3 , Aaron Ward 2 , David McCormack 4 , and Grace Parraga 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3 Graduate Program in Biomedical Engineering, The University of Western Ontario, London, Ontario, Canada, 4 Division of Respirology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada

Current methods for evaluating pulmonary ventilation heterogeneity from MRI are focused on quantifying ventilation defects although this measurement does not reflect ventilation patchiness or regional heterogeneity on smaller-volume or length scales. Hence, our objective was to develop a second-order texture analysis algorithm to quantify and characterize 3 He ventilation heterogeneity in healthy never-smokers and participants with respiratory disease. Preliminary results in a training dataset showed that 3 He MRI texture measurements correlated with spirometry (FEV1/FVC), 3 He VDP and Vencov in healthy never-smokers.

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