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Abstract #3984

Parallel Imaging for Short Breath Hold Times in Perfluorinated Gas Imaging of the Lung

Hal Cecil Charles 1 , Randall W. Jones 2 , Ahmed F. Halaweish 3 , and Maureen D. Ainslie 1

1 Radiology, Duke Image Analysis Laboratory, Duke University Medical School, Durham, NC, United States, 2 ScanMed, Omaha, Nebraska, United States, 3 Currently at Siemens Healthcare, MN, United States

Airway diseases (e.g. COPD and asthma) represent an economic burden in the US of approximately $100 billion annually and up to $90 billion annually, respectively. In order to fully understand lung function in airway disease a major challenge lies in the regional determination of poorly ventilated compartments in the lung. We have developed a method of imaging gas wash-in and wash-out that gives us a quantitative measure of mechanical ventilation the rate of gas replacement normalized to gas volume. We have implemented parallel imaging of perfluorinated gas/oxygen mixtures to shorten breath hold times in subjects with severe lung disease.

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