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Abstract #3986

MRI Measurements of Regional Ventilation Heterogeneity: Ventilation Defect Clusters

Dante Capaldi 1,2 , Khadija Sheikh 1,2 , Sarah Svenningsen 1,2 , Damien Pike 1,2 , David G McCormack 3 , and Grace Parraga 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3 Division of Respirology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada

Hyperpolarized noble gas MRI provides a way to visualize and regionally measure ventilation heterogeneity using the ventilation defect percent (VDP), although this normalized volume does not reflect spatial differences in subjects with the same VDP. We hypothesized that regional differences in ventilation heterogeneity are physiologically relevant, and hence the objective of this algorithm development project was to develop a way to spatially quantify ventilation heterogeneity obvious in thoracic 3He MRI. Preliminary results in COPD and bronchiectasis subjects with the same VDP showed spatially different ventilation heterogeneity similar to LCI measurements in the same subjects.

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