Functional MRI Ventilation Discriminates Well-controlled Asthmatic and Healthy Subjects: Sensitivity, Specificity and Comparison with FEV 1
Sarah Svenningsen 1,2 , Bastiaan Driehuys 3 , David G McCormack 4 , and Grace Parraga 1,2
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
of Radiology, Duke University, Durham, North Carolina,
of Respirology, Department of Medicine, The University
of Western Ontario, London, Ontario, Canada
To accelerate clinical translation and regulatory
approval of inhaled gas MRI of respiratory disease, the
etiology of ventilation defects must be determined and
validation with clinically-acceptable measurements, such
be undertaken. We compared the performance of
MRI ventilation and FEV
asthmatics and healthy volunteers.
MRI VDP and VenCOV provided diagnostic accuracy that was
similar to FEV
. Estimated likelihood ratios
suggested that the most accurate diagnosis of asthma was
MRI VDP. Next steps include testing more sensitive
MRI ventilation defects in the same validation model.
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