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Abstract #3989

Functional MRI Ventilation Discriminates Well-controlled Asthmatic and Healthy Subjects: Sensitivity, Specificity and Comparison with FEV 1

Sarah Svenningsen 1,2 , Bastiaan Driehuys 3 , David G McCormack 4 , and Grace Parraga 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3 Department of Radiology, Duke University, Durham, North Carolina, United States, 4 Division of Respirology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada

To accelerate clinical translation and regulatory approval of inhaled gas MRI of respiratory disease, the etiology of ventilation defects must be determined and validation with clinically-acceptable measurements, such as FEV 1 must be undertaken. We compared the performance of 3 He MRI ventilation and FEV 1 to discriminate asthmatics and healthy volunteers. 3 He MRI VDP and VenCOV provided diagnostic accuracy that was similar to FEV 1 . Estimated likelihood ratios suggested that the most accurate diagnosis of asthma was generated using 3 He MRI VDP. Next steps include testing more sensitive 129 Xe MRI ventilation defects in the same validation model.

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