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Abstract #3992

Bronchodilatation Effect on Alveolar Oxygen Partial Pressure and Gas Exchange Rate of Asthma Patients: First Results of Clinical Study

Maxim Terekhov 1 , Ursula Wolf 2 , Klaus K Gast 2 , Christian Hoffmann 2 , Sergei Karpuk 3 , Christian Mrozek 3 , Christoph Dueber 2 , and Laura Maria Schreiber 1

1 Radiology Department, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany, 2 Radiology Department, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany, 3 Institute of Physics, Johannes Gutenberg University, Mainz, Germany

In the present paper the intermediate results of open clinical study on HP-3He-MRI measurements performed in bronchial asthma patients are presented. The particular aim was to investigate the effect of bronchodilatation on the alveolar pO2 measured with 3He-MRI, and to correlate the variation with the pulmonary function tests (PFT). For the 50% of patient data analyzed up to now we confirmed tentatively the increase of aPO2 after BDL on about 5%. The median value of oxygen consumption rate appears to be unchanged after BDL. However, the heterogeneity of variation over the patients increases by at least 50%.

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