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Abstract #3991

Measurement of p A O 2 with Hyperpolarized 129 Xe: Correction for Signal Decay due to Gas Exchange.

Iga Muradyan 1 , Samuel Patz 1 , Mikayel Dabaghyan 2 , Mirko Hrovat 2 , and James P. Butler 1

1 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2 Mirtech, Inc., Brockton, MA, United States

Obtaining regional alveolar p A O 2 is a coveted goal in pulmonary medicine, as it reflects both ventilation and perfusion. Hyperpolarized gases, mostly 3 He were used to map p A O 2 . For 3 He this is straightforward as helium is virtually insoluble in tissue. Xe, however, dissolves into tissue and blood and is carried away from the alveolar space, thus contributes to the loss of the 129 Xe MRI signal. To date no attempt has been made to address this issue. Here we report a novel use of SB-XTC to measure p A O 2 while simultaneously measuring and taking into account xenon gas exchange on the signal decay.

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