Abstract #3991
Measurement of p A O 2 with Hyperpolarized 129 Xe: Correction for Signal Decay due to Gas Exchange.
Iga Muradyan 1 , Samuel Patz 1 , Mikayel Dabaghyan 2 , Mirko Hrovat 2 , and James P. Butler 1
1
Department of Radiology, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA, United
States,
2
Mirtech,
Inc., Brockton, MA, United States
Obtaining regional alveolar p
A
O
2
is
a coveted goal in pulmonary medicine, as it reflects
both ventilation and perfusion. Hyperpolarized gases,
mostly
3
He
were used to map p
A
O
2
. For
3
He
this is straightforward as helium is virtually insoluble
in tissue. Xe, however, dissolves into tissue and blood
and is carried away from the alveolar space, thus
contributes to the loss of the
129
Xe
MRI signal. To date no attempt has been made to address
this issue. Here we report a novel use of SB-XTC to
measure p
A
O
2
while
simultaneously measuring and taking into account xenon
gas exchange on the signal decay.
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