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Abstract #3995

Diffusion Imaging of Mouse Kidney with Oscillating Gradients: Feasibility Study

Hua Li 1 , Feng Wang 1 , Xiaoyu Jiang 1 , Junzhong Xu 1 , and John C. Gore 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Diffusion MRI imaging has previously been used to evaluate both structural and functional changes in various renal diseases. However, conventional pulsed gradient spin echo (PGSE) methods are highly sensitive to motion and flow artifacts. By contrast, oscillating gradient spin echo (OGSE) diffusion methods are less affected by bulk motion and the IVIM effect. In addition, OGSE methods may provide new insights into kidney microstructure at shorter length scales compared with PGSE. The goal of this study was to assess the feasibility of reliable in vivo diffusion measurements in kidneys with OGSE sequences.

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