Abstract #4008
Diffusion tensor imaging and multiparametric mapping of experimental acute and chronic kidney disease at 7T
Jutta Janke 1 , Gunnar Schley 2 , Michael Uder 1 , Kai-Uwe Eckardt 2 , Carsten Willam 2 , and Tobias Buerle 1
1
Institute of Radiology, University Hospital
Erlangen, Erlangen, Germany,
2
Nephrology
and Hypertensiology, University Hospital Erlangen,
Erlangen, Germany
Diffusion tensor imaging (DTI) is an emerging technique
for acquisition of renal pathologies. Combining DTI
parameters apparent diffusion coefficient (ADC) and
fractional anisotropy (FA) with mapping of relaxation
times (T1, T2, T2*) as well as volumetry of murine
kidneys at 7T ex vivo, we could differentiate
significantly between acute kidney failure and chronic
interstitial nephritis as compared to untreated
controls, respectively. Interestingly, tract alterations
were diagnosed and visualized between control and
pathologic kidneys as determined by DTI tractography. In
conclusion, DTI and multiparametric mapping at 7T
enables characterization and diagnosis of acute and
chronic kidney changes in experimental models.
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