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Abstract #4008

Diffusion tensor imaging and multiparametric mapping of experimental acute and chronic kidney disease at 7T

Jutta Janke 1 , Gunnar Schley 2 , Michael Uder 1 , Kai-Uwe Eckardt 2 , Carsten Willam 2 , and Tobias Buerle 1

1 Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 2 Nephrology and Hypertensiology, University Hospital Erlangen, Erlangen, Germany

Diffusion tensor imaging (DTI) is an emerging technique for acquisition of renal pathologies. Combining DTI parameters apparent diffusion coefficient (ADC) and fractional anisotropy (FA) with mapping of relaxation times (T1, T2, T2*) as well as volumetry of murine kidneys at 7T ex vivo, we could differentiate significantly between acute kidney failure and chronic interstitial nephritis as compared to untreated controls, respectively. Interestingly, tract alterations were diagnosed and visualized between control and pathologic kidneys as determined by DTI tractography. In conclusion, DTI and multiparametric mapping at 7T enables characterization and diagnosis of acute and chronic kidney changes in experimental models.

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