Abstract #4010
Non-invasive Assessment of Fibrosis and Inflammation in Rat Kidney Models with Diffusion-Weighted MRI
Lindsey Alexandra Crowe 1 , Iris Friedli 1 , Christian Vesin 2 , Lena Berchtold 3 , Pierre-Yves Martin 4 , Sophie de Seigneux 4 , and Jean-Paul Valle 1
1
Division of Radiology / Faculty of Medicine,
Geneva University Hospital, Geneva, Switzerland,
2
Division
of Cell Physiology and Metabolism, Geneva University
Hospital, Geneva, Switzerland,
3
Division
of General Internal Medicine, Geneva University
Hospital, Geneva, Switzerland,
4
Division
of Nephrology, Geneva University Hospital, Geneva,
Switzerland
We present readout-segmented diffusion at 3T (clinical
scanner) in rat with reduced EPI distortions. A
non-invasive technique to assess renal fibrosis and
inflammation is proposed and validated in different rat
model pathologies. In UUO (severe) and BSA (moderate),
ADC from segmented RESOLVE correlated with fibrosis
(p<0.001). For BSA with less fibrosis ADC difference
from control was significant (p=0.007) emphasizing
sensitivity (fibrosis <20%). There was correlation with
inflammation for UUO. Our results demonstrated the power
of RESOLVE. The proposed protocol may be easily
translated to the clinical practice to improve CKD
patient treatment and decrease significantly the need
for renal biopsy.
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