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Abstract #4010

Non-invasive Assessment of Fibrosis and Inflammation in Rat Kidney Models with Diffusion-Weighted MRI

Lindsey Alexandra Crowe 1 , Iris Friedli 1 , Christian Vesin 2 , Lena Berchtold 3 , Pierre-Yves Martin 4 , Sophie de Seigneux 4 , and Jean-Paul Valle 1

1 Division of Radiology / Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland, 2 Division of Cell Physiology and Metabolism, Geneva University Hospital, Geneva, Switzerland, 3 Division of General Internal Medicine, Geneva University Hospital, Geneva, Switzerland, 4 Division of Nephrology, Geneva University Hospital, Geneva, Switzerland

We present readout-segmented diffusion at 3T (clinical scanner) in rat with reduced EPI distortions. A non-invasive technique to assess renal fibrosis and inflammation is proposed and validated in different rat model pathologies. In UUO (severe) and BSA (moderate), ADC from segmented RESOLVE correlated with fibrosis (p<0.001). For BSA with less fibrosis ADC difference from control was significant (p=0.007) emphasizing sensitivity (fibrosis <20%). There was correlation with inflammation for UUO. Our results demonstrated the power of RESOLVE. The proposed protocol may be easily translated to the clinical practice to improve CKD patient treatment and decrease significantly the need for renal biopsy.

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